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PODCAST: Tremorgenic Mycotoxins

Tremorgenic mycotoxins produced by molds on foods are a relatively common — and possibly under-diagnosed — cause of tremors and seizures in pet animals. Because of their relatively indiscriminate appetites, dogs tend to be most commonly exposed to tremorgens. These toxins are produced by a variety of fungi, but tremorgens produced by Penicillium spp. are the most commonly encountered. The molds grow on practically any food, including dairy products, grains, nuts and legumes, and compost piles may also provide a source of tremorgens. Tremorgens have a several different mechanisms of action: some alter nerve action potentials, some affect neurotransmitter action, and others change neurotransmitter levels. The overall result is the development of muscle tremors and seizures.

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